General Cell Based Assays
Eurofins Discoverx PathHunter CCR2 Bioassay Kit, 2-Plate. (93-0192Y2-00061)
The PathHunter CCR2 Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. MCP-1/CCL2) based activation of CCR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCR2 and EA-tagged β-Arrestin-2. Activation of CCR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Sigma Aldrich Fine Chemicals Biosciences ATPase/GTPase Activity Assay Kit sufficient for 200 colorimetric tests | 1KT
ATPase/GTPase Activity Assay Kit sufficient for 200 colorimetric tests | 1KT
STEMCELL Technologies Ascorbic Acid, Size: 100 g
Support the proliferation of mesenchymal stem cells (Choi et al. J Biosci Bioeng, 2008) with Ascorbic Acid. Ascorbic Acid is a reducing agent that shows antioxidant activity against reactive oxygen species. Ascorbic Acid is used to differentiate mouse embryonic stem (ES) cells into osteoblasts (zur Nieden et al. Differentiation, 2003) and cardiomyocytes (Takahashi et al. Circulation, 2003). This small molecule also promotes differentiation of osteoblasts from human and mouse mesenchymal cells (Pittenger et al. Science, 1999; Tropel et al. Exp Cell Res, 2004) and increases the efficiency of reprogramming mouse and human fibroblasts to induced pluripotent stem (iPS) cells (Esteban et al. Cell Stem Cell, 2010). L-Ascorbic Acid is supplied as a crystalline solid with ≥95% purity; Molecular weight 176.1 g/mol; CAS Number 50-81-7. Visit STEMCELL.com for more information and related products.
Abcam Conjugation Check Kit
Conjugation Check Kit
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter eXpress GPR37 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0339E2ACP1L)
The PathHunter GPR37 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR37 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR37 and EA-tagged β-Arrestin-2. Activation of GPR37 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx InCELL Hunter eXpress CSNK1D Kinase Binding Assay, 10-plate Kit. (96-0048E15CP0L)
The InCELL Hunter eXpress CSNK1D Kinase Binding Assay provides an easy-to-use cell based assay to study small molecule drug candidates that engage with kinases. This kit assesses compound-engagement-based stabilization of CSNK1D via detection of CSNK1D levels. This product uses EFC technology. The cell line included overexpresses CSNK1D target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Abcam Secretory Phospholipase A2 Assay Kit
Secretory Phospholipase A2 Assay Kit
The product is subject to the following: Abcam Restricted Use Statement
Abcam Rhod-4 Calcium Assay Kit - No Wash
Rhod-4 Calcium Assay Kit - No Wash
The product is subject to the following: Abcam Restricted Use Statement
American Research Products Inc AMPK PHOSPHO KIT FLUOROMETRIC
5000265423 AMPK PHOSPHO KIT FLUOROMETRIC
Eurofins Discoverx PathHunter eXpress GIPR CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-1095E2CP2M)
The PathHunter GIPR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. GIP) based activation of GIPR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GIPR and EA-tagged β-Arrestin-2. Activation of GIPR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eagle Biosciences Inc Creatinine Microplate Assay Kit
Creatinine Assay Kit (urine normalizing assay)
Cayman Chemical MyeloperoxIdase MoncLNal n 1ea
Host: Mouse • Species Reactivity: (+) Human, mouse • Applications: IF
Cell Signaling Technology p4442 MAPK Erk12 137F5 Rabbit mAb InTraSeqtm 3 Conjugate 3016 25 ul
p4442 MAPK Erk12 137F5 Rabbit mAb InTraSeqtm 3 Conjugate 3016 25 ul
Dojindo Molecular Technologies Inc DNA DAMAGE QUANTIFIC KIT (20 SAMPLES) is a colorimetric microplate assay and can determine the number of abasic sites in genomic DNA samples.
Oxidative damage to DNA is a result of its interaction with reactive oxygen species (ROS), in particular the hydroxy radical. Hydroxy radicals, which are produced from superoxide anion and hydrogen peroxide by the Fenton reaction, produce multiple modifications in DNA. Oxidative attacks by hydroxy radicals on the deoxyribose moiety leads to the release of free bases from DNA, generating strand breaks with various sugar modifications and simple abasic sites (AP sites). In fact, AP sites are one of the major types of damage generated by ROS. The Aldehyde Reactive Probe reacts specifically with an aldehyde group present on the open ring form of the AP sites. DNA Damage Quantification Kit contains all the necessary solutions for detecting between 1 to 40 AP sites per 1 x 105 base pairs.